BDNF genetic variations increase the risk of Alzheimer's disease-related depression.

@article{Borroni2009BDNFGV,
  title={BDNF genetic variations increase the risk of Alzheimer's disease-related depression.},
  author={Barbara Borroni and Mario Grassi and Silvana Archetti and Chiara Costanzi and Marta Bianchi and Luigi Caimi and Carlo Caltagirone and Monica Di Luca and Alessandro Padovani},
  journal={Journal of Alzheimer's disease : JAD},
  year={2009},
  volume={18 4},
  pages={867-75}
}
The gene encoding the brain-derived neurotrophic factor (BDNF) has been demonstrated as a candidate for Alzheimer's disease-related depression (AD-D) susceptibility. Additionally, an association between AD-D and the functional valine to methionine (Val66Met) polymorphism has been reported. The aim of this study was to assess the genetic contribution of other BDNF variants to AD-D. Two-hundred forty-five AD patients were divided into two subgroups according to the presence (AD-D) or the absence… CONTINUE READING

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