BDNF gene effects on brain circuitry replicated in 455 twins

@article{Chiang2011BDNFGE,
  title={BDNF gene effects on brain circuitry replicated in 455 twins},
  author={Ming-Chang Chiang and Marina Barysheva and Arthur W. Toga and Sarah E. Medland and Narelle K. Hansell and Michael R. James and Katie L. McMahon and Greig I. de Zubicaray and Nicholas G. Martin and Margaret J. Wright and Paul M. Thompson},
  journal={NeuroImage},
  year={2011},
  volume={55 2},
  pages={448-54}
}
Brain-derived neurotrophic factor (BDNF) plays a key role in learning and memory, but its effects on the fiber architecture of the living brain are unknown. We genotyped 455 healthy adult twins and their non-twin siblings (188 males/267 females; age: 23.7±2.1 years, mean±SD) and scanned them with high angular resolution diffusion tensor imaging (DTI), to assess how the BDNF Val66Met polymorphism affects white matter microstructure. By applying genetic association analysis to every 3D point in… CONTINUE READING
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