BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

@article{Bramham2005BDNFFI,
  title={BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis},
  author={Clive R. Bramham and ElHoucine Messaoudi},
  journal={Progress in Neurobiology},
  year={2005},
  volume={76},
  pages={99-125}
}
Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain.
TLDR
By modulating the spatial and temporal translation of newly induced (Arc) and constitutively expressed mRNA in neuronal dendrites, BDNF may effectively control the window of synaptic consolidation, which has implications for mechanisms of memory storage and mood control.
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
TLDR
This review attempts to summarize the current knowledge in synaptic secretion and synaptic action ofBDNF, including both permissive and instructive effects of BDNF in synaptic plasticity.
BDNF and Hippocampal Synaptic Plasticity.
Cooperation between BDNF and glutamate in the regulation of synaptic transmission and neuronal development
TLDR
It is found that the effects of BDNF on dendritic growth of cortical neurons require both the stimulation of cAMP response element-binding protein (CREB) phosphorylation by BDNF and the activation of the CREB-regulated transcription coactivator 1 (CRTC1) by glutamate.
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Cooperation between BDNF and glutamate in the regulation of synaptic transmission and neuronal development.
TLDR
It is found that the effects of BDNF on dendritic growth of cortical neurons require both the stimulation of cAMP response element-binding protein (CREB) phosphorylation by BDNF and the activation of the CREB-regulated transcription coactivator 1 (CRTC1) by glutamate.
The requirement of BDNF for hippocampal synaptic plasticity is experience‐dependent
TLDR
The finding that both learning‐facilitated LTD and spatial reference memory are both impaired in BDNF+/− mice, suggests moreover, that it is critically required for the physiological encoding of hippocampus‐dependent memory.
LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function
TLDR
This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG) by investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein and changes in activation of the translation factors eIF4E and eEF2 during LTP.
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The results suggest that BDNF may regulate LTP in developing and adult hippocampus by enhancing synaptic responses to tetanic stimulation, and a TrkB–IgG fusion protein, which scavenges endogenous BDNF11, reduced the synaptic responses in adult hippocampus as well as the magnitude of LTP.
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A role for BDNF in triggering transcription-dependent, late phase LTP in the intact adult brain is supported and is associated with enhancement in both synaptic strength and granule cell excitability (EPSP–spike coupling).
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