BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures

  title={BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures},
  author={Viktorija Trajkovska and Martin A. Santini and Anders B. Marcussen and Morten S. Thomsen and Henrik H. Hansen and Jens D Mikkelsen and L. Arneberg and Merab Kokaia and G. M. Knudsen and Susana Aznar},
  journal={Neurochemistry International},

Changes in 5-HT 2A -mediated behavior and 5-HT 2A - and 5-HT 1A receptor binding and expression in conditional BDNF knock-out mice

These findings illustrate the context-dependent effects of deficient BDNF signaling on the 5-HT receptor system and5-HT 2A -receptor functional output and underlines the complexity of neurotrophin and serotonin signaling interaction.

5-HT 2A Receptors and BDNF Regulation: Implications for Psychopathology

This book chapter extensively reviewed the current understanding of the regulation ofBDNF by 5-HT2A receptors at multiple levels spanning from transcriptional regulation to modulation of BDNF signaling and suggests that such a crosstalk may play an important role in the actions of stress, antidepressant and atypical antipsychotic treatments, and in mediating hallucinogenic responses.

BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

Observations indicate that BDNF val66met polymorphism changes hippocampal synaptic plasticity via down-regulation of 5-HT3a receptors, which may underlie cognition dysfunction of Met allele carriers.

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem

5-HT–BDNF cross-talk is a potential target for the treatment of various neurological diseases and understanding the function of the members of BDNF system in response to challenges of the environment and the interaction with different 5-HT receptors in health and disease will one day lead to new classes of drugs.

Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain

In the present review, the results of the own research as well as data provided in the corresponding literature on the interaction of brain-derived neurotrophic factor (BDNF) and glial cell line- derived neurotrophic factors (GDNF) with the 5-HT-system of the brain are considered.

Cerebral 5-HT2A Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

  • A. KleinV. Trajkovska G. Knudsen
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2010
This study investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT2A) receptor or serotonin transporter (SERT) binding in healthy subjects, and found no statistically significant differences in 5- HT2A receptor or SERT binding were found between the val/val and met carriers.



Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities.

The results indicate that endogenous BDNF is critical for the normal development and function of central 5-HT neurons and for the elaboration of behaviors that depend on these nerve cells, and BDNF(+/-) mice may provide a useful model to study human psychiatric disorders attributed to dysfunction of serotonergic neurons.

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

It is suggested that postnatal levels of BDNF play a relatively limited role in maintaining presynaptic aspects of the serotonin system and a much greater role in maintain postsynaptic 5-HT2A and possibly other receptors than previously suspected.

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.

BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain

The results suggest that BDNF augments 5‐HT synthesis in vivo by directly enhancing steady‐state TPH mRNA levels, and subsequently leading to marked behavioral alterations.

Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor*

Results suggest a novel, protein synthesis-dependent form of BDNF modulation that requires cAMP gating.