BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures

@article{Trajkovska2009BDNFD5,
  title={BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures},
  author={Viktorija Trajkovska and Martin A. Santini and Anders B. Marcussen and Morten S. Thomsen and Henrik H. Hansen and Jens D Mikkelsen and L. Arneberg and Merab Kokaia and G. M. Knudsen and Susana Aznar},
  journal={Neurochemistry International},
  year={2009},
  volume={55},
  pages={697-702}
}

Changes in 5-HT 2A -mediated behavior and 5-HT 2A - and 5-HT 1A receptor binding and expression in conditional BDNF knock-out mice

TLDR
These findings illustrate the context-dependent effects of deficient BDNF signaling on the 5-HT receptor system and5-HT 2A -receptor functional output and underlines the complexity of neurotrophin and serotonin signaling interaction.

5-HT 2A Receptors and BDNF Regulation: Implications for Psychopathology

TLDR
This book chapter extensively reviewed the current understanding of the regulation ofBDNF by 5-HT2A receptors at multiple levels spanning from transcriptional regulation to modulation of BDNF signaling and suggests that such a crosstalk may play an important role in the actions of stress, antidepressant and atypical antipsychotic treatments, and in mediating hallucinogenic responses.

BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

TLDR
Observations indicate that BDNF val66met polymorphism changes hippocampal synaptic plasticity via down-regulation of 5-HT3a receptors, which may underlie cognition dysfunction of Met allele carriers.

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem

TLDR
5-HT–BDNF cross-talk is a potential target for the treatment of various neurological diseases and understanding the function of the members of BDNF system in response to challenges of the environment and the interaction with different 5-HT receptors in health and disease will one day lead to new classes of drugs.

Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain

TLDR
In the present review, the results of the own research as well as data provided in the corresponding literature on the interaction of brain-derived neurotrophic factor (BDNF) and glial cell line- derived neurotrophic factors (GDNF) with the 5-HT-system of the brain are considered.

Cerebral 5-HT2A Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

  • A. KleinV. Trajkovska G. Knudsen
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2010
TLDR
This study investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT2A) receptor or serotonin transporter (SERT) binding in healthy subjects, and found no statistically significant differences in 5- HT2A receptor or SERT binding were found between the val/val and met carriers.

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TLDR
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TLDR
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TLDR
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