BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy.

@article{Shi2012BDNFBC,
  title={BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy.},
  author={Wei Shi and Dekang Nie and Guohua Jin and Weiwei Chen and Liang Xia and Xiu-Jie Wu and Xing Su and Xide Xu and Lanchun Ni and Xianan Zhang and Xinhua Zhang and Jianchu Chen},
  journal={Biomaterials},
  year={2012},
  volume={33 11},
  pages={3119-26}
}
This study tested the cytotoxicity of a BDNF blended chitosan scaffold with human umbilical cord mesenchymal stem cells (hUC-MSCs), and the in vitro effect of BDNF blended chitosan scaffolds on neural stem cell differentiation with the aim of contributing alternative methods in tissue engineering for the treatment of traumatic brain injury (TBI). The chitosan scaffold based on immobilization of BDNF by genipin (GP) as a crosslinking agent referred to hereafter as a CGB scaffold was prepared by… CONTINUE READING

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