BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

@article{Lu2013BDNFbasedSR,
  title={BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases},
  author={Bai Lu and Guhan Nagappan and Xiaoming Guan and Pradeep J. Nathan and Paul B. Wren},
  journal={Nature Reviews Neuroscience},
  year={2013},
  volume={14},
  pages={401-416}
}
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes — including episodic memory and hippocampal volume — and the technological progress in measuring synaptic changes in humans all pave the way… 
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