BDNF acting in the hypothalamus induces acute pressor responses under permissive control of angiotensin II.

Abstract

Brain-derived neurotrophic factor (BDNF) expression increases in the paraventricular nucleus of the hypothalamus (PVN) during hypertensive stimuli including stress and hyperosmolarity, but its role in PVN cardiovascular regulatory mechanisms is unclear. Chronic BDNF overexpression in the PVN has been shown to elevate sympathetic tone and blood pressure in… (More)
DOI: 10.1016/j.autneu.2016.02.011

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