BDCA2/FcɛRIγ Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells

@article{Cao2007BDCA2FcRICS,
  title={BDCA2/FcɛRIγ Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells},
  author={Wei Cao and Li Zhang and David B. Rosen and Laura C Bover and Gokuran Watanabe and Musheng Bao and Lewis L. Lanier and Yong-Jun Liu},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={255 - 258}
}
Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lacking an identifiable signaling motif. We demonstrate here that BDCA2 forms a complex with the transmembrane adapter Fc epsilon RI gamma. Through pathway analysis, we identified a comprehensive signaling machinery in human pDCs, similar to that which… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 80 references

Dendritic cells: translating innate to adaptive immunity.

Current topics in microbiology and immunology • 2006
View 7 Excerpts
Highly Influenced

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 1 Excerpt

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