BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood

@article{Dzionek2000BDCA2BA,
  title={BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood},
  author={Andrzej Dzionek and Anja G. Fuchs and Petra Schmidt and Sabine Cremer and Monika Zysk and Stefan Miltenyi and David William Buck and Jürg Schmitz},
  journal={The Journal of Immunology},
  year={2000},
  volume={165},
  pages={6037 - 6046}
}
Key ResultWe have generated a panel of mAbs that identify three presumably novel human dendritic cell Ags: BDCA-2, BDCA-3, and BDCA-4. In blood, BDCA-2 and BDCA-4 are expressed on CD11c(-) CD123(bright) plasmacytoid dendritic cells, whereas BDCA-3 is expressed on small population of CD11c(+) CD123(-) dendritic cells. All three Ags are not detectable on a third blood dendritic cell population, which is CD1c(+) CD11c(bright) CD123(dim), or on any other cells in blood.Expand
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TLDR
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Use of anti-BDCA-2 antibody for detection of dendritic cells type-2 (DC2) in allogeneic hematopoietic stem cell transplantation
TLDR
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