BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies.

@article{Robak2013BCRSI,
  title={BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies.},
  author={Tadeusz Robak and Pawel Robak},
  journal={International reviews of immunology},
  year={2013},
  volume={32 4},
  pages={358-76}
}
Normal B lymphocytes receive signals from B-cell antigen receptor (BCR) that are triggered by binding of the BCR to an external antigen. Tonic signaling through the BCR provides growth and signals to chronic lymphocytic leukemia (CLL) cells, and plays an important role in the pathogenesis and progression of the disease. Antigen engagement of BCR is followed… CONTINUE READING