BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

@article{Pendergast1991BCRSE,
  title={BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner},
  author={A. Pendergast and A. J. Muller and M. Havlik and Y. Maru and O. Witte},
  journal={Cell},
  year={1991},
  volume={66},
  pages={161-171}
}
  • A. Pendergast, A. J. Muller, +2 authors O. Witte
  • Published 1991
  • Biology, Medicine
  • Cell
  • BCR-ABL is a chimeric oncogene implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. BCR first exon sequences specifically activate the tyrosine kinase and transforming potential of BCR-ABL. We have tested the hypothesis that activation of BCR-ABL may involve direct interaction between BCR sequences and the tyrosine kinase regulatory domains of ABL. Full-length c-BCR as well as BCR sequences retained in BCR-ABL bind specifically to the SH2 domain of ABL. The… CONTINUE READING
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