BCR-ABL mutants spread resistance to non-mutated cells through a paracrine mechanism

@article{Liu2008BCRABLMS,
  title={BCR-ABL mutants spread resistance to non-mutated cells through a paracrine mechanism},
  author={J Liu and Sami Joha and Thierry Idziorek and S{\'e}lim Corm and Dominique H{\'e}tuin and Nathalie Philippe and Claude Joseph Preudhomme and Bruno Quesnel},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={791-799}
}
Patients with chronic myeloid leukemia who become resistant to the Abl kinase inhibitor imatinib can be treated with dasatinib. This sequential treatment can lead to BCR-ABL mutations conferring broad resistance to kinase inhibitors. To model the evolution of resistance, we exposed the mouse DA1-3b BCR-ABL+ leukemic cell line to imatinib for several months… CONTINUE READING