BCR-ABL kinase is dead; long live the CML stem cell.

  title={BCR-ABL kinase is dead; long live the CML stem cell.},
  author={Alexander Perl and Martin Carroll},
  journal={The Journal of clinical investigation},
  volume={121 1},
Chronic myeloid leukemia (CML) is a hematopoietic disease characterized by expansion of myeloid blood cells. It is caused by the t(9;22) chromosomal translocation that results in the expression of the fusion tyrosine kinase BCR-ABL. Tyrosine kinase inhibitor (TKI) therapy has led to long-term remissions, but patients remain BCR-ABL+. There is agreement that TKIs do not kill CML stem cells; however, it is controversial whether this is because of a lack of BCR-ABL kinase inhibition in CML stem… CONTINUE READING


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