BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.

@article{Soverini2011BCRABLKD,
  title={BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.},
  author={Simona Soverini and Andreas Hochhaus and Franck Emmanuel Nicolini and Franz Gruber and Thoralf Lange and Giuseppe Saglio and Fabrizio Pane and Martin Christian M{\"u}ller and Thomas O G Ernst and Gianantonio Rosti and Kimmo V.K. Porkka and Michele Baccarani and Nicholas C P Cross and Giovanni Martinelli},
  journal={Blood},
  year={2011},
  volume={118 5},
  pages={1208-15}
}
Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the European LeukemiaNet (ELN) and European Treatment and Outcome Study and are here reported. Based on a critical review of the literature and, whenever necessary, on panelists' experience… CONTINUE READING
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High frequency of point mutations clustered within the BCR-ABL MUTATION ANALYSIS IN CML 1213 BLOOD

  • S Branford, Z Rudzki, S Walsh
  • For personal use only. on July 15,
  • 2011
1 Excerpt

A review of mutation analysis in the TOPS trial of standard versus high dose IM in CML suggests that refinements to the ELN recommendations for mutation screening may be appropriate [abstract

  • S Branford, H-G Goh, B Izzo
  • Blood (ASH Annual Meeting Abstracts)
  • 2010

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