BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

@article{Donato2003BCRABLIA,
  title={BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.},
  author={Nicholas J. Donato and Ji Yuan Wu and Jonathan Stapley and Gary E. Gallick and Hui Lin and Ralph B. Arlinghaus and Moshe Talpaz},
  journal={Blood},
  year={2003},
  volume={101 2},
  pages={690-8}
}
Clinical studies have shown that the tyrosine kinase inhibitor STI571 effectively controls BCR-ABL-positive chronic myelogenous leukemia (CML). However, disease progression while on STI571 therapy has been reported, suggesting de novo or intrinsic resistance to BCR-ABL-targeted therapy. To investigate possible mediators of acquired STI571 resistance, K562 cells resistant to 5 microM STI571 (K562-R) were cloned and compared to the parental cell population. K562-R cells had reduced BCR-ABL… CONTINUE READING
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