BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.

@article{Parada2001BCRABLAI,
  title={BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.},
  author={Y Parada and Lolita Banerji and Janet Glassford and Nicholas C Lea and Manuel Collado and Carmen Rivas and John L. Lewis and Myrtle Y A Gordon and N. S. Thomas and Eric W-F Lam},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={23572-80}
}
Although it is evident that BCR-ABL can rescue cytokine-deprived hematopoietic progenitor cells from cell cycle arrest and apoptosis, the exact mechanism of action of BCR/ABL and interleukin (IL)-3 to promote proliferation and survival has not been established. Using the pro-B cell line BaF3 and a BaF3 cell line stably overexpressing BCR-ABL (BaF3-p210), we investigated the proliferative signals derived from BCR-ABL and IL-3. The results indicate that both IL-3 and BCR-ABL target the expression… CONTINUE READING

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