BCR / ABL mRNA and the P 210 BCR / ABL Protein Are Downmodulated by Interferon-a in Chronic Myeloid Leukemia Patients

Abstract

The BCR/ABL hybrid gene plays a central role in the pathogenesis of the chronic phase of chronic myeloid leukemia (CML). We used a very sensitive quantitative reverse transcriptase-polymerase chain reaction to investigate the levels of hybrid BCR/ABL mRNA in bone marrow cells of 20 patients with Philadelphia positive (Ph1) CML treated with interferon-a (IFN… (More)

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