BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold

@article{Dierov2009BCRABLIC,
  title={BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold},
  author={Jamil K Dierov and Patricia Vanessa Sanchez and Beth A. Burke and Hesed M. Padilla-Nash and Mary E. Putt and Thomas Ried and Martin Carroll},
  journal={Leukemia},
  year={2009},
  volume={23},
  pages={279-286}
}
Earlier reports have suggested that the BCR/ABL oncogene, associated with chronic myeloid leukemia, induces a mutator phenotype; however, it is unclear whether this leads to long-term changes in chromosomes and whether the phenotype is found in primary chronic myelogeneous leukemia (CML) cells. We have addressed both these issues. BCR/ABL-expressing cell… CONTINUE READING