BCR/ABL alters the function of NK cells and the acquisition of killer immunoglobulin-like receptors (KIRs).

@article{Chiorean2003BCRABLAT,
  title={BCR/ABL alters the function of NK cells and the acquisition of killer immunoglobulin-like receptors (KIRs).},
  author={Elena Gabriela Chiorean and Scott J. Dylla and Krista Olsen and Todd R. Lenvik and Yvette Soignier and Jeffrey S Miller},
  journal={Blood},
  year={2003},
  volume={101 9},
  pages={3527-33}
}
Natural killer (NK) cells decrease in function during chronic myelogenous leukemia (CML) progression from chronic phase to blast crisis, and they can become BCR/ABL(+) late in the disease course. To study this altered function, NK92 cells were transduced with the BCR/ABL oncogene. In contrast to the parental cells, which died when deprived of interleukin 2 (IL-2), p210(+) NK92 cells proliferated and survived indefinitely in the absence of IL-2. BCR/ABL also decreased the natural cytotoxicity of… CONTINUE READING