BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13.

@article{Molloy2007BCPCI,
  title={BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13.},
  author={Eamonn S. Molloy and Maria P. Morgan and Barry J. McDonnell and John M. O'Byrne and Geraldine Mccarthy},
  journal={Osteoarthritis and cartilage},
  year={2007},
  volume={15 4},
  pages={
          414-20
        }
}

Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts.

It is suggested that non-selective COX inhibition may be preferable to COX-2 selective inhibition in BCP crystal-associated OA and that BCP crystals can augment PG production in OASF through induction ofCOX-1 and COx-2.

Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2

BCP crystal induction of MMP-13 expression may involve the ERK1/2 and p38 MAPK pathways and activation of nuclear factor κB; this upregulation of M MP-13 may contribute to the accelerated cartilage breakdown in BCP crystal-associated osteoarthritis.

Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals

Overexpression of A5 and the presence of BCP crystals observed in advanced osteoarthritis contributed to chondrocyte apoptosis, and the results suggest a new pathophysiological mechanism for calcium-containing crystal arthropathies.

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

The recent advances in studies using pharmacological approaches, genetically modified animals, and genome-wide association studies regarding the roles of IP and EP1–4 receptors in the immune, cardiovascular, nervous, gastrointestinal, respiratory, genitourinary, and musculoskeletal systems are discussed.

The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs

Results indicated that articular chondrocytes in Hartley guinea pigs exhibited a hypertrophic phenotype and recapitulated a developmental molecular program similar to the endochondral pathway of ossification, suggesting that PC and PC analogues exerted their OA disease-modifying activity, in part, by inhibiting this molecular program.

Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis.

This article investigates the use of o-cresolphthalein complexone (OCP), a colorimetric reagent, to quantify calcium from crystals isolated from synovial fluid samples as a means of identifying the presence of BCP and, hence, improving the diagnosis of OA.

Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis

Enhanced effort is needed to establish calcium-containing crystals as a therapeutic target in OA, as current data suggest an intimate association in its pathogenesis and progression.

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Children with JIA exhibited a significantly higher salivary antioxidant activity and significantly lower MMP levels, suggesting anti-TNF treatment may modulate the degradation process during the course of arthritis by inhibition of the activity of MMP.

Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis

Abnormal biomechanical loading leads to enhanced formation of chondrocyte-derived exosomes, in which promoters of calcification increased and inhibitors decreased, resulting in accelerating abnormal cartilage calcification in TMJ OA.

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