BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2.

@article{Gollub2009BCL6translocationsAT,
  title={BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2.},
  author={Wiebke Gollub and Bj{\"o}rn Stassek and Torge Huckhagel and Heinz-Wolfram Bernd and Manuela Krokowski and Hartmut Merz and Alfred Christian Feller and Christoph Thorns},
  journal={Anticancer research},
  year={2009},
  volume={29 11},
  pages={4649-55}
}
BACKGROUND The translocation t(14;18)IgH/BCL2 is the molecular hallmark of follicular lymphomas (FL). A subset of cases harbours translocations involving the BCL6-gene locus. This study aimed to determine the frequency of BCL2- and BCL6-translocations in FL and to identify morphological and immuno-histochemical features with respect to the presence of BCL2- and BCL6-translocations. MATERIALS AND METHODS Fluorescence-in-situ-hybridisation (FISH) was used to determine the BCL2- and BCL6… CONTINUE READING