BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription

@article{BrockeHeidrich2006BCL3II,
  title={BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription},
  author={K Brocke-Heidrich and Bing Ge and Helena Cvijic and Gabriele Pfeifer and Dennis Loeffler and Christian Henze and T. Mckeithan and Friedemann Horn},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={7297-7304}
}
BCL3 is a proto-oncogene affected by chromosomal translocations in some patients with chronic lymphocytic leukemia. It is an IκB family protein that is involved in transcriptional regulation of a number of NF-κB target genes. In this study, interleukin (IL)-6-induced BCL3 expression and its effect on survival of multiple myeloma (MM) cells were examined. We demonstrate the upregulation of BCL3 by IL-6 in INA-6 and other MM cell lines. Sequence analysis of the BCL3 gene locus revealed four… CONTINUE READING
Highly Cited
This paper has 55 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Role of Bcl-3 in solid tumors

Molecular Cancer • 2011
View 8 Excerpts
Highly Influenced

56 Citations

051015'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Cell 72: 729–739

Brasier AR, Lu M, Hai T, Lu Y, Boldogh I. (2001). J Biol • 1993
View 3 Excerpts
Highly Influenced

Blood 103: 242–251

D Loffler, D Koczan
Bundy DL, McKeithan TW. (1997). J Biol Chem 272: • 2004

Cell 110: 55–67

MG.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown • 2002

Hematol J 2: 42–53

W Baum
Chatterjee M, Stuhmer T, Herrmann P, Bommert K, Dorken • 2001

Cell 55: 875–885

P Angel, K Hattori, T Smeal, M. Karin
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld • 1988
View 1 Excerpt