BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3.

@article{Hishiki2007BCL3AA,
  title={BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3.},
  author={Takayuki Hishiki and Takayuki Ohshima and Takeshi Ego and Kunitada Shimotohno},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 39},
  pages={28335-43}
}
By associating with cyclic AMP-responsive element-binding protein (CREB), the human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates transcription from the HTLV-1 long terminal repeat (LTR), which contains multiple cyclic AMP-responsive elements. The transducers of regulated CREB activity (TORCs) were a recently identified family of CREB co-activators that bind to CREB to enhance CRE-mediated transcription. TORC3, a TORC family protein, dramatically enhances Tax-mediated… CONTINUE READING