BCL2-modifying factor promotes germ cell loss during murine oogenesis.

@article{Vaithiyanathan2016BCL2modifyingFP,
  title={BCL2-modifying factor promotes germ cell loss during murine oogenesis.},
  author={K. Vaithiyanathan and S. Liew and N. Zerafa and Thilini Gamage and M. Cook and L. O'reilly and P. Bouillet and C. Scott and A. Strasser and J. Findlay and K. Hutt},
  journal={Reproduction},
  year={2016},
  volume={151 5},
  pages={
          553-62
        }
}
Apoptosis plays a prominent role during ovarian development by eliminating large numbers of germ cells from the female germ line. However, the precise mechanisms and regulatory proteins involved in germ cell death are yet to be determined. In this study, we characterised the role of the pro-apoptotic BH3-only protein, BCL2-modifying factor (BMF), in germ cell apoptosis in embryonic and neonatal mouse ovaries. BMF protein was immunohistochemically localised to germ cells at embryonic days 15.5… Expand
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