BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

  title={BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.},
  author={Meike Vogler and Hassan A. Hamali and Xiao-ming Sun and Edward T. W. Bampton and David Dinsdale and Roger T. Snowden and Martin J. S. Dyer and Alison H. Goodall and Gerald M. Cohen},
  volume={117 26},
Apoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen after platelet activation is poorly understood. ABT-263 (Navitoclax), a specific inhibitor of antiapoptotic BCL2 proteins, which is currently being evaluated in clinical trials for the treatment of leukemia and other malignancies, induces a dose-limiting thrombocytopenia. In this study, the relationship between BCL2/BCL-X(L) inhibition… 

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The role of apoptosis in megakaryocytes and platelets

  • B. Kile
  • Biology
    British journal of haematology
  • 2014
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HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP 3 receptor / Bcl-2 complexes.

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