BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

@article{Vogler2011BCL2BCLXLII,
  title={BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.},
  author={M. Vogler and Hassan A. A. Hamali and X. Sun and E. Bampton and D. Dinsdale and R. Snowden and M. Dyer and A. Goodall and G. Cohen},
  journal={Blood},
  year={2011},
  volume={117 26},
  pages={
          7145-54
        }
}
Apoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen after platelet activation is poorly understood. ABT-263 (Navitoclax), a specific inhibitor of antiapoptotic BCL2 proteins, which is currently being evaluated in clinical trials for the treatment of leukemia and other malignancies, induces a dose-limiting thrombocytopenia. In this study, the relationship between BCL2/BCL-X(L) inhibition… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Bcl-2 family proteins are essential for platelet survival
  • 303
  • PDF
Constitutive Death of Platelets Leading to Scavenger Receptor-mediated Phagocytosis
  • 175
  • PDF
Programmed Anuclear Cell Death Delimits Platelet Life Span
  • 772
...
1
2
3
4
5
...