BCL-W has a fundamental role in B cell survival and lymphomagenesis.

  title={BCL-W has a fundamental role in B cell survival and lymphomagenesis.},
  author={Clare M. Adams and Annette S. Kim and Ramkrishna Mitra and John Kim Choi and Jerald Z. Gong and Christine M. Eischen},
  journal={The Journal of clinical investigation},
  volume={127 2},
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival. The antiapoptotic proteins of the BCL-2 family are key regulators of cell survival and are frequently overexpressed in malignancies, leading to increased cancer cell survival. Unlike BCL-2 and BCL-XL, the closest antiapoptotic relative BCL-W is required for spermatogenesis, but was… CONTINUE READING
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