BCL-6 oncoprotein in breast cancer: loss of expression in disease progression.

  title={BCL-6 oncoprotein in breast cancer: loss of expression in disease progression.},
  author={Ant{\'o}nio Evaristo Pinto and Saudade P Andr{\'e} and Giovani Silva and Sara Vieira and Ana Cristina Santos and S{\'e}rgio Luiz Vaz Dias and Jorge Fernando Maxnuck Soares},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  volume={76 5},
OBJECTIVE To investigate the biological role of BCL-6 oncoprotein in breast cancer disease progression (recurrence and metastasis). METHODS The series consisted of 93 consecutive female patients with primary breast cancer and median follow-up of 10 years. BCL-6 expression was assessed in vivo by immunohistochemistry and real-time PCR. Breast cancer cell lines and some metastasis-related genes (CXCR4, Itgbeta-3 and FLT-1) were also analysed by molecular techniques. Prognostic evaluation was… CONTINUE READING
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