BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production.

@article{Yu2005BCL6NR,
  title={BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production.},
  author={Raymond Yick-Loi Yu and Xiaoxia Wang and Fiona J Pixley and J. Jessica Yu and Alexander L Dent and Hal E. Broxmeyer and E Richard Stanley and B Hilda Ye},
  journal={Blood},
  year={2005},
  volume={105 4},
  pages={1777-84}
}
The transcription repressor BCL-6 is known to play critical roles in B-cell lymphomagenesis, germinal center formation, and balanced Th1/Th2 differentiation. In macrophages, although BCL-6 has also been shown to regulate the expression of several chemokine genes, its function in other aspects of macrophage biology has not been studied. In addition, the precise role of BCL-6 in cell proliferation is poorly understood in general. Here we report that BCL-6(-/-) macrophages hyperproliferate due to… CONTINUE READING