BCL-2 stimulates Apoptin-induced apoptosis.

  title={BCL-2 stimulates Apoptin-induced apoptosis.},
  author={Astrid A A M Danen-van Oorschot and Alex J van der Eb and Mathieu H. M. Noteborn},
  journal={Advances in experimental medicine and biology},
Apoptin, a protein encoded by an avian virus, induces apoptosis in various cultured human tumorigenic and/or transformed cell lines, e.g. in leukemia, lymphoma or EBV-transformed B cells. In such cells, Apoptin induces p53-independent apoptosis, and the proto-oncogene Bcl-2 accelerates this effect. The latter is surprising for, in general, Bcl-2 is known to inhibit e.g., p53-induced apoptosis. On the other hand, in normal non-transformed human cells, Apoptin is unable to induce apoptosis, even… CONTINUE READING
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