BCL-2 stimulates Apoptin-induced apoptosis.

@article{Oorschot1999BCL2SA,
  title={BCL-2 stimulates Apoptin-induced apoptosis.},
  author={Astrid A A M Danen-van Oorschot and Alex J van der Eb and Mathieu H. M. Noteborn},
  journal={Advances in experimental medicine and biology},
  year={1999},
  volume={457},
  pages={245-9}
}
Apoptin, a protein encoded by an avian virus, induces apoptosis in various cultured human tumorigenic and/or transformed cell lines, e.g. in leukemia, lymphoma or EBV-transformed B cells. In such cells, Apoptin induces p53-independent apoptosis, and the proto-oncogene Bcl-2 accelerates this effect. The latter is surprising for, in general, Bcl-2 is known to inhibit e.g., p53-induced apoptosis. On the other hand, in normal non-transformed human cells, Apoptin is unable to induce apoptosis, even… CONTINUE READING
22 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…