BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice.

@article{Raghupathi1998BCL2OA,
  title={BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice.},
  author={Ramesh Raghupathi and SystemsJ. Cl. Fernandez and Hisayoshi Murai and Stephen P Trusko and Richard W. Scott and Walter K. Nishioka and Tracy K Mcintosh},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1998},
  volume={18 11},
  pages={1259-69}
}
The proto-oncogene, BCL-2, has been suggested to participate in cell survival during development of, and after injury to, the CNS. Transgenic (TG) mice overexpressing human Bcl-2 (n = 21) and their wild-type (WT) littermates (n = 18) were subjected to lateral controlled cortical impact brain injury. Lateral controlled cortical impact brain injury resulted… CONTINUE READING