BCL-2 in prostate cancer: A minireview

@article{Catz2004BCL2IP,
  title={BCL-2 in prostate cancer: A minireview},
  author={Sergio D. Catz and J Johnson},
  journal={Apoptosis},
  year={2004},
  volume={8},
  pages={29-37}
}
Prostate cancer progression and the development of androgen-independent prostate cancer have been largely related to a number of genetic abnormality that affect not only the androgen receptor but also crucial molecules involved in the regulation of survival or apoptotic pathways. One of these molecules, the pro-survival protein BCL-2, has been associated with the development of androgen-independent prostate cancer due to its high levels of expression in androgen-independent tumors in advanced… 

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References

SHOWING 1-10 OF 115 REFERENCES

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

TLDR
It is indicated that bcl-2 expression is augmented following androgen ablation and is correlated with the progression of prostate cancer from androgen dependence to androgen independence.

Expression of bcl-2 and the progression of human and rodent prostatic cancers.

TLDR
The data demonstrate that the development of androgen independence and/or metastatic ability can be associated with the expression of bcl-2 protein but that b cl-2-independent mechanisms also exist for such progression.

Antagonism between PTEN/MMAC1/TEP-1 and Androgen Receptor in Growth and Apoptosis of Prostatic Cancer Cells*

TLDR
The data suggest that the loss of PTEN function may induce tumorigenesis through unopposed activity of the AR as well as contribute to the resistance of prostate cancers to androgen ablation therapy.

PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression*

TLDR
It is demonstrated that expression of Bcl-2 in prostate tumors correlates with loss of the PTEN protein, thus contributing to survival and chemoresistance of PCa cells and suggesting that thePTEN gene and its regulated pathway are potential therapeutic targets in prostate cancer.

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

TLDR
It is suggested that expression of several anti-apoptotic members of the bcl-2 gene family, including b cl-2, bcl -X, and mcl-1 increases during progression of prostate cancers, a finding that may be relevant to the hormone-insensitive, metastatic phenotype of most advanced adenocarcinomas of the prostate.

The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer.

  • K. FizaziL. A. Martinez N. Navone
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2002
TLDR
Tumor relapse, defining AIPC, was associated with increased expression of p21 to levels comparable with those found before castration, and p21 expression at relapse was also correlated with a high Ki-67 index.

Apoptosis: therapeutic significance in the treatment of androgen-dependent and androgen-independent prostate cancer

TLDR
The results suggest that treatment of prostate cancer patients with suramin prior to irradiation is likely to inhibit radiation palliation, and that radiation therapy followed by suramin treatment may yield enhanced effectiveness.

Androgens down-regulate bcl-2 protooncogene expression in ZR-75-1 human breast cancer cells.

TLDR
It is indicated that androgens can down-regulate bcl-2 protooncogene levels via an androgen receptor-mediated mechanism, thus providing a novel mechanism for their known inhibitory effect on breast cancer cell growth.

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state.

TLDR
Data show that androgen ablation alone can increase PI3K-Akt activation, which supports survival after acute androgens ablation and proliferation during chronic androgen deprivation, and successful progression to the androgen-independent state in the LNCaP cell line model requires intact PI3k signaling.

Role of the Bcl-2 gene family in prostate cancer progression and its implications for therapeutic intervention.

TLDR
In vitro and in vivo studies have established that Bcl-2 expression confers an antiapoptotic activity against androgen withdrawal and cytotoxic chemotherapy, which offers a tempting potential target for therapeutic manipulations of PC.
...