BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.

@article{Jans1999BCL2BP,
  title={BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.},
  author={David Andrew Jans and Vivien Sutton and Patricia Jans and Christopher J. Froelich and Joseph A. Trapani},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 7},
  pages={3953-61}
}
Cytolytic granule-mediated target cell killing is effected in part through the synergistic action of the membrane-acting protein perforin and serine proteases such as granzymes (Gr) A and B. In this study, we examine the subcellular distribution of granzymes in the presence of perforin and the induction of apoptosis in mouse FDC-P1 myeloid and YAC-1 lymphoma cells that express the proto-oncogene bcl2. Using confocal laser scanning microscopy to visualize and quantitate subcellular transport of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006

Unlocking the secrets of cytotoxic granule proteins.

Journal of leukocyte biology • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…