BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis.

@article{Kerr2002BCL2AB,
  title={BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis.},
  author={Douglas J. A. Kerr and Thomas B Larsen and Susan H Cook and Yih-Ru Fannjiang and Eunkyung Choi and Diane E Griffin and J Marie Hardwick and David N. Irani},
  journal={Journal of virology},
  year={2002},
  volume={76 20},
  pages={
          10393-400
        }
}
  • Douglas J. A. Kerr, Thomas B Larsen, +5 authors David N. Irani
  • Published in Journal of virology 2002
  • Biology, Medicine
  • Cellular proteins that regulate apoptotic cell death can modulate the outcome of Sindbis virus (SV) encephalitis in mice. Both endogenous and overexpressed BCL-2 and BAX proteins protect newborn mice from fatal SV infection by blocking apoptosis in infected neurons. To determine the effects of these cellular factors on the course of infection in older animals, a more neurovirulent SV vector (dsNSV) was constructed from a viral strain that causes both prominent spinal cord infection with hind… CONTINUE READING

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