BCL-2: pro-or anti-oxidant?

  title={BCL-2: pro-or anti-oxidant?},
  author={Zhi Xiong Chen and Shazib Pervaiz},
  journal={Frontiers in bioscience},
Bcl-2 is recognized as an oncoprotein via its ability to impede death signaling by sequestrating pro-apoptotic proteins such as Bax and Bak as well as preserving mitochondrial outer membrane integrity. Recently, a growing body of evidence has evaluated the role of Bcl-2 in intracellular redox regulation and its downstream effects on life and death decisions in cancer cells. On the backdrop of these findings, we discuss here the classical anti-apoptotic role of Bcl-2 in malignant cells, and… CONTINUE READING

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