BCL-2/IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular lymphoma: results of a prospective randomized EORTC 20981 phase III intergroup study.

@article{Oers2010BCL2IgHPC,
  title={BCL-2/IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular lymphoma: results of a prospective randomized EORTC 20981 phase III intergroup study.},
  author={Marinus H. J. van Oers and Evelyn R L T M T{\"o}nnissen and M van Glabbeke and Livia Giurgea and Joop H Jansen and Richard Klasa and Robert E. Marcus and Max Wolf and Eva K Kimby and Andrej Vranovsk{\'y} and Harald H. Holte and Anton Hagenbeek and Bert A van der Reijden},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 13},
  pages={2246-52}
}
PURPOSE The prognostic value of residual BCL2/immunoglobulin heavy chain (BCL2/IgH) -positive cells in peripheral blood (PB) or bone marrow (BM) after induction treatment in follicular lymphoma (FL) is still controversial. In a prospective randomized phase III intergroup trial of 465 patients with relapsed/resistant follicular lymphoma (FL), we showed that addition of rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone induction results in increased overall and complete… CONTINUE READING

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