BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

@inproceedings{Oppenheim2014BCKDHTM,
  title={BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei},
  author={Rebecca D. Oppenheim and Darren John Creek and James I. MacRae and Katarzyna K Modrzynska and Paco Pino and Julien Limenitakis and Val{\'e}rie Polonais and F. Mihura Seeber and Michael P. Barrett and Oliver Billker and Malcolm J. McConville and Dominique Soldati-Favre},
  booktitle={PLoS pathogens},
  year={2014}
}
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle. However, these parasites lack a mitochondrial isoform of pyruvate dehydrogenase and the identity of the enzyme that catalyses the conversion of pyruvate to acetyl-CoA remains enigmatic. Here we demonstrate that the mitochondrial branched chain ketoacid dehydrogenase… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii.

  • International journal for parasitology
  • 2018
VIEW 10 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 77 REFERENCES

Similar Papers

Loading similar papers…