BCG vaccines: their mechanisms of attenuation and impact on safety and protective efficacy.

@article{Liu2009BCGVT,
  title={BCG vaccines: their mechanisms of attenuation and impact on safety and protective efficacy.},
  author={Jun Liu and Vanessa Tran and Andrea S. Leung and David C. Alexander and Baoli Zhu},
  journal={Human vaccines},
  year={2009},
  volume={5 2},
  pages={70-8}
}
Mycobacterium bovis Bacille Calmette-Guérin (BCG) was developed as an attenuated live vaccine for tuberculosis control nearly a century ago. Despite being the most widely used vaccine in human history, the mechanisms of attenuation of BCG remain poorly understood. BCG is not a single organism, but comprises a number of substrains that differ in genotypes and phenotypes. The impacts of these differences on BCG vaccine properties are largely unknown. Nevertheless, in the past decade, the… CONTINUE READING

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