BCG vaccine: WHO position paper, February 2018 - Recommendations.

@article{Organization2018BCGVW,
  title={BCG vaccine: WHO position paper, February 2018 - Recommendations.},
  author={World Health Organization},
  journal={Vaccine},
  year={2018},
  volume={36 24},
  pages={
          3408-3410
        }
}
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94 Citations
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94 Citations

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A review of the BCG vaccine and other approaches toward tuberculosis eradication
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Recent data suggests the vaccine imparts protection against both tuberculosis and non-tuberculosis pathogens via a newly discovered immune system called trained immunity, and how the different strains of the BCG vaccine elicit different immune responses, suggesting that certain BCG strains are more immunogenic than others.
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The broad immune training effects of BCG vaccination and literature on the effects ofBCG vaccination on COVID-19 spread, disease severity, and mortality are explored and barriers to scheduled BCG vaccinations in the United States are discussed.
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Current vaccination strategies are discussed, directions for the possible routes towards the development of new TB vaccines are provided, and recent findings are highlighted.
Exploring the effects of BCG vaccination in patients diagnosed with tuberculosis: Observational study using the Enhanced Tuberculosis Surveillance system.
Clinical Development of New TB Vaccines: Recent Advances and Next Steps
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These findings provide encouraging evidence for pre-exposure and post-ex exposure approaches to vaccination against tuberculosis, both of which may be necessary to rapidly interrupt the cycle of Mtb transmission and sustain long-term impact on global tuberculosis control.
Effectiveness of booster BCG vaccination in preventing Covid-19 infection
TLDR
The findings demonstrated the potential effectiveness of the booster BCG vaccine, specifically the booster in preventing Covid-19 infections in an elevated-risk healthcare population.
Children with lymphadenitis associated with Bacillus Calmette-Guérin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: a three years paired-cohort in Mexico
TLDR
This cohort strongly suggests thatBCG-LA in healthy children is not associated with more episodes of AINF and hospitalizations, when paired and compared with children BCG-vaccinated without BCg-LA.
After 100 Years of BCG Immunization against Tuberculosis, What Is New and Still Outstanding for This Vaccine?
TLDR
The current thoughts about some of the latest findings and outstanding questions that I consider worth investigating to help develop a replacement or modified BCG in order to successfully fight TB, based on BCG itself are presented.
Research and development of new tuberculosis vaccines: a review.
TLDR
This presentation highlights the extraordinary progress being made to develop new TB vaccines and provided a clear picture of the exciting development pathways that are being explored.
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