BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control

@article{Merle2010BCGVA,
  title={BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control},
  author={Corinne SC Merle and S{\'e}rgio Souza da Cunha and Laura Cunha Rodrigues},
  journal={Expert Review of Vaccines},
  year={2010},
  volume={9},
  pages={209 - 222}
}
The bacillus Calmette–Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of published data including recently published studies (up to June 2009) to determine the efficacy of BCG protection on leprosy and to investigate whether age at vaccination, clinical… 
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The trial has shown that BCG provides only a very modest level of protection and thatBCG vaccination is not likely to be an important solution for leprosy control and the results are compared with those of three other major BCG trials inLeprosy.
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Findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic, and suggest that smallpox immunization had no effect.
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TLDR
The presence of BCG was negatively associated with leprosy, indicating a 5.3 risk of leproSy for those nonvaccinated and protective efficacy of 81%.
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TLDR
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TLDR
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