BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1.

  title={BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1.},
  author={Xiangbing Meng and Huimei Lu and Zhiyuan Shen},
  journal={Cell cycle},
  volume={3 11},
The BCCIP protein is a BRCA2 and CDKN1A (p21(Waf1/Cip1)) Interacting Protein, which binds to a highly conserved domain of BRCA2, and a C-terminal domain of the CDK-inhibitor p21. We have previously reported that overexpression of BCCIP increases p21 mRNA and protein levels, and inhibits G(1) to S progression. In this report, we show that a partial shutdown of BCCIP expression by RNA interference reduces p21 levels and impairs G(1)/S checkpoint activation in response to ionizing radiation in… CONTINUE READING

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