BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

@inproceedings{Papathanassiu2017BCAT1CM,
  title={BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases},
  author={Adonia E. Papathanassiu and Jeong-Hun Ko and Martha Imprialou and Marta Bagnati and Prashant Kumar Srivastava and Hong Anh Thi Vu and Danilo Cucchi and Stephen Mcadoo and Elitsa A Ananieva and Claudio Mauro and Jacques Behmoaras},
  booktitle={Nature communications},
  year={2017}
}
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show that BCAT1 is the predominant BCAT isoform in human primary macrophages. We identify ERG240 as a leucine analogue that blocks BCAT1 activity. Selective inhibition of BCAT1 activity results in decreased oxygen consumption and glycolysis. This… CONTINUE READING
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