BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.

@article{Duggan2017BCAPIP,
  title={BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.},
  author={Jeffrey M Duggan and Matthew B. Buechler and Rebecca M Olson and Tobias M. Hohl and Jessica A. Hamerman},
  journal={Blood},
  year={2017},
  volume={129 11},
  pages={1503-1513}
}
B-cell adaptor for phosphatidylinositol 3-kinase (BCAP) is a signaling adaptor expressed in mature hematopoietic cells, including monocytes and neutrophils. Here we investigated the role of BCAP in the homeostasis and development of these myeloid lineages. BCAP-/- mice had more bone marrow (BM) monocytes than wild-type (WT) mice, and in mixed WT:BCAP-/- BM… CONTINUE READING