BC200 RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD)

@article{Lukiw2004BC200RI,
  title={BC200 RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD)},
  author={Walter J. Lukiw and P. Handley and L. Wong and D. R. Crapper McLachlan},
  journal={Neurochemical Research},
  year={2004},
  volume={17},
  pages={591-597}
}
BC200 RNA is a polyadenylated 200 nucleotide primate brain-specific transcript with 80% homology to the left monomer of the human Alu family of repetitive elements. Whether this transcription product contributes anything to normal brain gene function or is a residue of post transcriptional processing of brain heterogeneous nuclear RNA (hnRNA) is uncertain. However, the high abundance, tissue-specific expression and nucleotide sequence characteristics of BC200 RNA suggests that the generation of… 
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References

SHOWING 1-10 OF 33 REFERENCES
Cytoskeletal messenger RNA stability in human neocortex: studies in normal aging and in Alzheimer's disease.
TLDR
The authors' observations indicate that for the cytoskeletal RNA messages studied here: short postmortem intervals had only small effects upon RNA quality in these neocortices, and each RNA species in normal human brain had both unique and characteristic intracellular levels of abundance and decay kinetics.
Characterization of messenger RNA from the cerebral cortex of control and Alzheimer-afflicted brain
TLDR
A significant reduction in the levels and proportion of poly(A)+ mRNA in the Alzheimer samples as compared to control brain samples suggests a cause-and-effect relationship.
Selective messenger RNA reduction in Alzheimer's disease.
TLDR
The anomalous low abundance of neuron specific NF-L mRNA, coding for the lowest molecular weight moiety of neurofilament proteins, in cerebral cortex of Alzheimer's disease cannot be adequately accounted for by a non-specific effect of brain damage, neuron cell loss or neurons with neurofibrillary degeneration.
Altered expression of genes for amyloid and cytoskeletal proteins in alzheimer cortex
TLDR
A general deficit in neuronal mRNAs is found in brains having marked AD‐type degeneration, including that for APP, which does not exclude the possibility of elevated levels of the message for the APP in small neuronal subsets, in subcortical neurons projecting to cortex, or as a generalized phenomenon in earlier stages of the disease.
Recovery and measurement of specific RNA species from postmortem brain tissue: a general reduction in Alzheimer's disease detected by molecular hybridization.
TLDR
In a comparison between frontal cortex samples from neurologically normal and Alzheimer's disease cases a reduction in ribosomal, poly A, preproenkephalin, and preprosomatostatin RNA levels was observed in the Alzheimer's Disease group, which may be influenced by the cause of death as well as the pathology.
Messenger RNA in the Brain
TLDR
The coupling of molecular genetics with anatomy and cytology should provide a powerful new approach toward gaining an understanding of brain function in the context of specialized cell populations.
A Comparative Study of the Diversity of Gene Expression in Brain
TLDR
The findings suggest that, as is the case in mammals, the diversity of gene expression in the CNS of teleosts and cephalopod mollusks is greater than in non-neural tissue, but the differences in the complexity of goldfish and squid brain RNA relative to that of non-NEural tissue is significantly less than that observed in several mammalian species.
Gene expression in rat brain.
TLDR
From these data, it is estimated that there are probably at most 30,000 distinct mRNA species expressed in the rat brain, the majority of which are uniquely expression in the brain.
Chromatin structure in dementia
TLDR
Nuclei extracted from neocortex of patients with Alzheimer's disease and treated with micrococcal nuclease release a population of dinucleosomes that contain an increase in the linker histones H1° and H1ºº, which support the hypothesis that an alteration in chromatin structure is a marker for Alzheimer's Disease.
Identifier sequences are transcribed specifically in brain
TLDR
The data suggest a model in which brain-specific polymerase III transcription of ID sequences located in introns of brain genes activates those genes in a primary manner for polymerase II transcription.
...
1
2
3
4
...