BBS4 directly affects proliferation and differentiation of adipocytes

BBS4 is one of several proteins whose defects cause Bardet–Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syndromic morbid obesity. BBS4 obesity molecular mechanisms, and the role of the BBS4 gene in adipocyte differentiation and function are not entirely known. We… CONTINUE READING