BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors

@inproceedings{Xu2015BBS4AB,
  title={BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors},
  author={Qingwen Xu and Yuxia Zhang and Qing Wei and Yan Huang and Yan Li and Kun Ling and Jinghua Hu},
  booktitle={Scientific reports},
  year={2015}
}
Cilia harbor sensory receptors for various signaling cascades critical for vertebrate development. However, the mechanisms underlying the ciliary homeostasis of sensory receptors remain elusive. Here, we demonstrate that BBS-4 and BBS-5, two distinct BBSome components, show unexpected functional redundancy in the context of cilia in C. elegans. BBS-4 directly interacts with BBS-5 and the interaction can be disrupted by a conserved mutation identified in human BBS4. Surprisingly, we found that… CONTINUE READING
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