BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis

@inproceedings{Liu2017BBC3IM,
  title={BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis},
  author={Haijun Liu and Yusi Cheng and Jing Yang and Wei Wang and Shencun Fang and Wei Zhang and Bing Han and Zewei Zhou and Honghong Yao and Jie Chao and Hong Liao},
  booktitle={Cell death & disease},
  year={2017}
}
Following inhalation into the lungs, silica particles are engulfed by alveolar macrophages, which triggers endogenous or exogenous apoptosis signaling pathways. As an inducer of apoptosis, the role of BBC3/PUMA (BCL2-binding component 3) in macrophages during silicosis remains unknown. Here, we exposed U937 cell-derived macrophages (UDMs) to SiO2 in vitro to explore the function of BBC3 in SiO2-induced disease. We found that SiO2 induced increased BBC3 expression, as well as macrophage… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 60 references

MCPIP1 Regulates Alveolar Macrophage Apoptosis and Pulmonary Fibroblast Activation After in vitro Exposure to Silica.

Toxicological sciences : an official journal of the Society of Toxicology • 2016
View 1 Excerpt

MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts.

American journal of physiology. Lung cellular and molecular physiology • 2016
View 2 Excerpts

iNOS Induces Vascular Endothelial Cell Migration and Apoptosis Via Autophagy in Ischemia/Reperfusion Injury.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2016
View 1 Excerpt

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