BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina

@inproceedings{Harder2011BBC3R,
  title={BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina},
  author={Jeffrey M Harder and Richard T Libby},
  booktitle={Molecular Neurodegeneration},
  year={2011}
}
Naturally occurring apoptosis is a developmental process that shapes the retina by eliminating overproduced neurons. In the absence of the proapoptotic Bcl-2 family member BAX, developmental apoptosis in the retina is disrupted and extra neurons survive. It is unknown how BAX is activated or if this regulation varies between neuronal types and subtypes. Since the Bcl-2 family members BIM, BID, and BBC3 (PUMA) are powerful direct activators of BAX, we used mice deficient for each of these genes… CONTINUE READING