BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein.

@article{Koenigs2013BBA70OB,
  title={BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein.},
  author={Arno Koenigs and Claudia Hammerschmidt and Brandon Lyon Jutras and Denys Pogoryelov and Diana Barthel and Christine Skerka and Dominik Kugelstadt and Reinhard Wallich and Brian Stevenson and Peter F Zipfel and Peter Kraiczy},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 35},
  pages={25229-43}
}
The Lyme disease spirochete Borrelia burgdorferi lacks endogenous, surface-exposed proteases. In order to efficiently disseminate throughout the host and penetrate tissue barriers, borreliae rely on recruitment of host proteases, such as plasmin(ogen). Here we report the identification of a novel plasminogen-binding protein, BBA70. Binding of plasminogen is dose-dependent and is affected by ionic strength. The BBA70-plasminogen interaction is mediated by lysine residues, primarily located in a… CONTINUE READING
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