BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro.

@article{McKenniff1991BAYUA,
  title={BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro.},
  author={M G McKenniff and Paul M. Norman and N J Cuthbert and Peggy Gardiner},
  journal={British journal of pharmacology},
  year={1991},
  volume={104 3},
  pages={585-90}
}
1. BAY u3405 (3(R)-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4- tetrahydro-9H-carbazole-9-propanoic acid) has been evaluated on airway smooth muscle, from a number of species including man, for its thromboxane A2 (TXA2) antagonist activity. 2. BAY u3405 was a potent, and competitive, antagonist of the TXA2-mimetic U46619-induced contractions of human, guinea-pig, rat and ferret airway smooth muscle with pA2 values between 8.0 and 8.9 and with no inherent contractile activity (10(-9)-10(-4) M… CONTINUE READING

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