BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

@article{Reli2016BAY1I,
  title={BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death},
  author={B. Reli{\'c} and E. Charlier and C. Deroyer and O. Malaise and S. Neuville and Aline Desoroux and P. Gillet and D. de Seny and M. Malaise},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={23370 - 23382}
}
  • B. Relić, E. Charlier, +6 authors M. Malaise
  • Published 2016
  • Biology, Medicine
  • Oncotarget
  • Inhibition of proapoptotic pathways in synovial fibroblasts is one of the major causes of synovial proliferation and hyperplasia in rheumatic diseases. We have shown previously that NF-κB inhibitor BAY 11-7085, through inactivation of PPAR-γ, induces apoptosis in human synovial fibroblasts. In this work we showed that BAY 11-7085 induced autophagy that preceded BAY 11-7085-induced apoptosis. Of interest, BAY 11-7085 induced Serine 211 phosphorylation and degradation of glucocorticoid receptor… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 55 REFERENCES
    Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
    • 1,019
    • PDF
    Life and death partners: apoptosis, autophagy and the cross-talk between them
    • 965
    • PDF
    Modulation of PPAR activity via phosphorylation.
    • 357
    Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
    • 250
    • Highly Influential
    • PDF
    PPAR gamma and human metabolic disease.
    • 335
    A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1*
    • 239
    • PDF
    Physiological significance of selective degradation of p62 by autophagy
    • 403
    • PDF
    Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
    • 247
    • PDF
    Autophagy modulates osteoarthritis-related gene expression in human chondrocytes.
    • 157
    • PDF